Will pilocarpine help lubricate my vagina

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. RATIONALE: Pilocarpine may decrease vaginal dryness and improve quality of life in patients with breast cancer It is not yet known whether pilocarpine is more effective than a placebo in treating vaginal dryness in patients with breast cancer. Patients are randomized to 1 of 4 treatment arms.

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The body's immune system attacks glands that secrete fluid, such as the tear and saliva glands. In women who are most commonly affectedthe glands that keep the vagina moist can also be affected, leading to vaginal dryness. There is a deficiency of the watery component of the tears.

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To evaluate the effect of Carbopol gel formulations containing pilocarpine on the morphology and morphometry of the vaginal epithelium of castrated rats. Persistent estrus Group I was achieved with a subcutaneous injection of testosterone propionate on the second postnatal day. Next, all of the animals were euthanized and their vaginas were removed for histological evaluation.

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Vaginal dryness is a common problem, for which effective and safe non-estrogenic treatments are needed. Based on preliminary promising data that pilocarpine attenuated vaginal dryness, the current trial was conducted. A double-blind, placebo-controlled, randomized trial design was used to compare pilocarpine, at target doses of 5 mg twice daily and 5 mg four times daily, to a placebo.

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There are several different types of drops that can be bought from pharmacies without a prescription. You may need to try a few types to find one that works for you. If you use eye drops more than three times a day, avoid drops that contain preservatives as these can damage your eyes if used frequently.

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A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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You might notice inflammation if you have a cut or a wound. It causes the affected area to hurt and turn red. It may also become hot, as fluid rushes to the area and causes swelling. This causes your eyes and mouth to become dry.

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Many patients have a mild disease that only affects the eyes and mouth. Others have symptoms that wax and wane in severity, or may even go into remission. Some have severe and chronic long-term symptoms.

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In women who are most commonly affectedthe glands that keep the vagina moist can also be affected, leading to vaginal dryness. The reasons for this remains unknown, but research suggests that it's triggered by a combination of genetic, environmental and, possibly, hormonal factors. Some people are thought to be more vulnerable to the syndrome when they're born and that certain events, such an infection, can trigger the problems with the immune system. Your doctor will ask about your symptoms and carry out a test to see how dry your mouth and eyes are.

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