Brca mutation breast cancer

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Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast-ovarian cancer syndrome in affected persons. Having a high-risk mutation does not guarantee that the woman will develop any type of cancer, or imply that any cancer that appears was actually caused by the mutation, rather than some other factor.

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Normal cells in the body grow, divide, and are replaced on a routine basis. Sometimes, cells divide abnormally and begin to grow out of control. These cells may form growths or tumors.

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BRCA mutations increase the risk of several other types of cancer as well. Since a BRCA mutation is such a significant risk factor, many women with a family history of the disease are encouraged to get genetic testing to see if they have one. Such testing is not routine and requires thoughtful consideration about potential next steps should results be positive.

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They are also at increased risk of developing prostate cancer. Research on the PALB2 gene continues. While the risk for male breast, pancreatic, and ovarian cancers is thought to be increased, the exact degree of increase remains under investigation.

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It also has information on genetic testing and other topics. Every cell in your body contains genes. Genes contain the blueprints genetic code for your body.

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Genes are the small sections of DNA that code for individual traits. For example, someone with naturally red hair has a gene that causes his or her hair to be red. All inherited traits are passed down through genes.

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Patients are becoming increasingly aware of the BRCA genes. However, many questions still exist about what they are and their link to hereditary breast and ovarian cancer, as well as other cancers. Here are answers to commonly asked questions. The BRCA genes are tumor suppressor genes.

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Research led by the University of Birmingham has found important new ways that the BRCA1 gene functions which could help develop our understanding of the development of ovarian and breast cancers. The research, published in Nature today July 3rdwas led by experts at the University of Birmingham's Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences and is part of a five-year research project which is playing a pivotal role in identifying and understanding breast cancer genes. First author Manolo Daza-Martin, of the University of Birmingham, explained: "No two people are born the same and, as a result, we all have slightly different chances of developing diseases during our lifetimes -- this is the result of natural variation in our genes.

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When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer. People who have inherited mutations in BRCA1 and BRCA2 tend to develop breast and ovarian cancers at younger ages than people who do not have these mutations.


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